Kinetic parameters associated with acyclovir and probe substrate transport by OAT1 and OAT3
Transport efficiency was determined by dividing the Jmax value by the Km value. Kinetics of OAT1- and OAT3-mediated acyclovir transport and probe substrate transport were conducted on the same day using cells of the same passage. n = 1 passage.
| Transporter | Substrate | Jmax | Km | Transport Efficiency |
|---|---|---|---|---|
| pmol · min−1 · mg protein−1 | μM | μl · min−1 · mg protein−1 | ||
| OAT1 | Acyclovir | 434 | 839 | 0.5 |
| OAT1 | PAH | 426 | 28 | 15 |
| OAT3 | Acyclovir | 797 | 772 | 1.0 |
| OAT3 | ES | 636 | 17 | 37 |