Pharmacokinetic parameters (mean ± S.D.) of morinidazole and four major metabolites in plasma after an intravenous infusion of 500 mg of morinidazole to 12 healthy Chinese subjects
| Parameters | Morinidazole | M4-1 | M7 | M8-1 | M8-2 |
|---|---|---|---|---|---|
| tmax, h | 0.681 ± 0.181 | 2.40 ± 0.91 | 1.04 ± 0.17 | 1.56 ± 0.53 | 1.54 ± 0.38 |
| Cmax, ng/ml | 10,853 ± 2246 | 48.6 ± 19.6 | 170 ± 51 | 248 ± 62 | 2065 ± 586 |
| AUC0-t, ng · h · ml−1 | 74,866 ± 12,687 | 612 ± 243 | 1702 ± 449 | 2965 ± 750 | 17,164 ± 4082 |
| AUC0–∞, ng · h · ml−1 | 75,964 ± 12,745 | 640 ± 239 | 1747 ± 460 | 3052 ± 778 | 17,417 ± 4122 |
| t1/2, h | 6.15 ± 0.59 | 6.37 ± 0.67 | 7.04 ± 0.56 | 6.96 ± 0.81 | 4.23 ± 0.45 |
| CLR, l/h | 1.44 ± 0.2 | 10.8 ± 5.1 | 49.5 ± 10.6 | 18.3 ± 3.2 | 13.7 ± 3.9 |