TABLE 3

Predicted median pharmacokinetic parameters from a single-dose and 14-day multiple dose simulation of 60 mg of raloxifene q.d. compared with the clinically derived parameters

Source for data: Hochner-Celnikier (1999); Morello et al. (2003); Physicians' Desk Reference (2005).

Parameter	Single Dose		Multiple Dose
Parameter	CL_{p.o. clinical}	CL_{p.o. Simcyp}	CL_{p.o clinical}	CL_{p.o. Simcyp}	CL_{HIM+HLM Simcyp}
Duration of study, days	5	14
T_max, h	0.5^{^a}	0.7
C_max, μg/l	0.5^{^a}	0.5	1.36^{^a}	1.24	1.8
AUC_0–∞, μg · h⁻¹ · l⁻¹	27.2^{^a}	20.3	24.2^{^a}	24.6	38
CL/F, l/h	3087^{^a}	3367	3318^{^a}	2702	2700

↵a Data matched well compared with the published literature.