Parameter | Single Dose | Multiple Dose | |||
---|---|---|---|---|---|
CLp.o. clinical | CLp.o. Simcyp | CLp.o clinical | CLp.o. Simcyp | CLHIM+HLM Simcyp | |
Duration of study, days | 5 | 14 | |||
Tmax, h | 0.5a | 0.7 | |||
Cmax, μg/l | 0.5a | 0.5 | 1.36a | 1.24 | 1.8 |
AUC0–∞, μg · h−1 · l−1 | 27.2a | 20.3 | 24.2a | 24.6 | 38 |
CL/F, l/h | 3087a | 3367 | 3318a | 2702 | 2700 |
↵a Data matched well compared with the published literature.