TABLE 3

The pharmacokinetic parameters of TRZ, ROS, WAR, and MEP administered orally in cassette dosing after repeated intraperitoneal administration of RIF once daily for 4 days to the male PXB mice

Each value was determined from the data shown in Fig. 1. Data represent the mean ± S.D. of three mice.

		RIF Dose	C_max	t_1/2	AUC_0-∞	AUC Decrease
		mg/kg	ng/ml	h	ng · h/ml	%
CYP3A4	TRZ	Vehicle	824 ± 92	0.733 ± 0.066	1210 ± 110
		2	643 ± 72^*	0.775 ± 0.055	650 ± 117^**	46
		10	408 ± 45^**	0.699 ± 0.109	561 ± 205^***	54
		50	531 ± 43^***	0.575 ± 0.028	346 ± 27^***	71
CYP2C8	ROS	Vehicle	1970 ± 240	1.07 ± 0.13	4960 ± 770
		2	1920 ± 210	1.10 ± 0.18	4120 ± 680	17
		10	1900 ± 350	0.911 ± 0.075	3690 ± 860	26
		50	1850 ± 330	0.772 ± 0.058	2630 ± 900^*	47
CYP2C9	WAR	Vehicle	680 ± 26	ND	3830 ± 60
		2	640 ± 161	ND	3120 ± 830	19
		10	709 ± 197	ND	3420 ± 610	11
		50	715 ± 5	ND	3160 ± 400	18
CYP2C19	MEP	Vehicle	951 ± 250	0.757 ± 0.249	1240 ± 230
		2	955 ± 150	0.683 ± 0.144	844 ± 173	32
		10	894 ± 102	0.660 ± 0.155	876 ± 84	30
		50	730 ± 61	0.524 ± 0.120	685 ± 198^*	46

ND, not determined.
↵ Statistically significant from the vehicle-treated group: * P < 0.05;
↵** P < 0.01;
↵*** P < 0.001.