TABLE 2

Pharmacokinetic parameters of CP-945,598 and CE-156,706, and total radioactivity in humans after a single 25-mg oral dose of [¹⁴C]CP-945,598

Analyte	Subject	T_max	C_max	AUC0_0-last	AUC0_0-∞	T_1/2
		h	ng/ml	ng · h⁻¹ · ml⁻¹		h
CP-945,598	1-1001	6	15.4	633	690	166
	2-1002	6	10.8	517	561	102
	3-1004	6	15.7	1092	1227	174
	4-1007	4	16.3	879	992	187
	5-1009	8	9.79	770	849	165
	Mean ± S.D.	6.0 ± 1.4	14 ± 3.1	778 ± 223	864 ± 260	159 ± 33
M1 (CE-156,706)	1-1001	6	50.0	3443	3651	138
	2-1002	6	46.7	4071	4177	111
	3-1004	6	43.8	4018	4243	129
	4-1007	8	35.9	3741	4087	162
	5-1009	8	35.7	3384	3672	155
	Mean ± S.D.	6.8 ± 1.1	42 ± 6.4	3731 ± 317	3966 ± 284	139 ± 20
Total radioactivity	1-1001	6	68.4	8219	9127	165
	2-1002	6	88.6	9438	10960	197
	3-1004	4	68.7	7438	8626	201
	4-1007	6	79.0	8623	9352	177
	5-1009	8	65.7	7774	9107	210
	Mean ± S.D.	6.0 ± 1.4	74 ± 9.6	8298 ± 779	9434 ± 893	190 ± 18