Analyte | Subject | Tmax | Cmax | AUC00-last | AUC00-∞ | T1/2 |
---|---|---|---|---|---|---|
h | ng/ml | ng · h−1 · ml−1 | h | |||
CP-945,598 | 1-1001 | 6 | 15.4 | 633 | 690 | 166 |
2-1002 | 6 | 10.8 | 517 | 561 | 102 | |
3-1004 | 6 | 15.7 | 1092 | 1227 | 174 | |
4-1007 | 4 | 16.3 | 879 | 992 | 187 | |
5-1009 | 8 | 9.79 | 770 | 849 | 165 | |
Mean ± S.D. | 6.0 ± 1.4 | 14 ± 3.1 | 778 ± 223 | 864 ± 260 | 159 ± 33 | |
M1 (CE-156,706) | 1-1001 | 6 | 50.0 | 3443 | 3651 | 138 |
2-1002 | 6 | 46.7 | 4071 | 4177 | 111 | |
3-1004 | 6 | 43.8 | 4018 | 4243 | 129 | |
4-1007 | 8 | 35.9 | 3741 | 4087 | 162 | |
5-1009 | 8 | 35.7 | 3384 | 3672 | 155 | |
Mean ± S.D. | 6.8 ± 1.1 | 42 ± 6.4 | 3731 ± 317 | 3966 ± 284 | 139 ± 20 | |
Total radioactivity | 1-1001 | 6 | 68.4 | 8219 | 9127 | 165 |
2-1002 | 6 | 88.6 | 9438 | 10960 | 197 | |
3-1004 | 4 | 68.7 | 7438 | 8626 | 201 | |
4-1007 | 6 | 79.0 | 8623 | 9352 | 177 | |
5-1009 | 8 | 65.7 | 7774 | 9107 | 210 | |
Mean ± S.D. | 6.0 ± 1.4 | 74 ± 9.6 | 8298 ± 779 | 9434 ± 893 | 190 ± 18 |