Dantrolene AUC changes in wild-type and knockout mice
Dantrolene blood, brain, and CSF AUC in wild-type and Mdr1a/1b and Bcrp knockout mice were determined, and AUC ratios were calculated.
| AUC Ratio | Bcrp(−/−) | Mdr1a/1b(−/−) | Mdr1a/1b(−/−)/Bcrp(−/−) |
|---|---|---|---|
| AUCblood, KO/WT | 0.91 | 0.98 | 1.42 |
| AUCbrain, KO/WT | 2.94 | 1.10 | 4.67 |
| AUCCSF, KO/WT | 2.25 | 1.10 | 3.81 |
| AUCbrain/blood, KO/WT | 3.24 | 1.13 | 3.29 |
| AUCCSF/blood, KO/WT | 2.48 | 1.13 | 2.68 |
| AUCCSF/brain, KO/WT | 0.77 | 1.00 | 0.82 |
KO, knockout; WT, wild type.