Pharmacokinetic parameters of mirabegron in plasma and urine and for radioactivity in plasma, blood, and urine after a single oral administration of 160 mg of [14C]mirabegron to healthy volunteers
Values of pharmacokinetic parameters are means ± S.D.; n = 4.
| Parameter | Mirabegron | Radioactivity | |||
|---|---|---|---|---|---|
| Plasma | Urine | Plasma | Blood | Urine | |
| tmax, h | 1.00 ± 0.71 | 2.25 ± 1.44 | 2.13 ± 1.44 | ||
| Cmax, ng/ml | 371 ± 96 | 879 ± 279a | 777 ± 211a | ||
| AUCinf, ng · h/ml | 2285 ± 250 | 10443 ± 2328a | 13896 ± 2979a | ||
| t1/2, h | 47.9 ± 8.1 | 72.9 ± 13.0 | 28.2 ± 5.4 | 30.5 ± 4.0 | 84.5 ± 11.6 |
| CL/F, l/h | 70.7 ± 7.63 | ||||
| VZ/F, liters | 4824 ± 501 | ||||
| CLR, l/h | 17.7 ± 2.14 | ||||
↵a Radioactivity data were transformed into mirabegron equivalent concentrations (nanogram equivalents per milliliter) by multiplying with the specific activity of [14C]mirabegron.