Pharmacokinetic parameters in rats and dogs after intravenous administration of [14C]M-III
Dose: 0.5 mg/kg. Data are mean values ± S.D. (n = 3).
| Rat | Dog | |
|---|---|---|
| C5 min, μg/ml | 2.288 ± 0.179 | 4.687 ± 0.436 |
| t1/2λ, h | 4.1 ± 1.5 | 120 ± 30 |
| AUCinf, μg · h/ml | 0.802 ± 0.110 | 596 ± 157 |
| CLtot, ml · h−1 · kg−1 | 631 ± 86 | 0.884 ± 0.260 |
| Vd, ml/kg | 140 ± 5 | 98.9 ± 13.2 |
| kel (1/h) × 10−3 | 184 ± 58 | 6.04 ± 1.60 |