Druga | Primary UGTb | CLint, u, UGT | Ratio of CLint, u, UGT | ||||
---|---|---|---|---|---|---|---|
HLM | HKM | HIM | Kidney/Liver | Intestine/Liver | Kidney/Intestine | ||
ml · min−1 · g tissue−1 | scaled per g tissue | ||||||
Diclofenac | 1A9/2B7 | 47.4 (7.8) | 6.95 (1.15) | 6.70 | 0.147 | 0.141 | 1.04 |
Ezetimibe | 1A1 | 207 (23) | 6.34 (1.34) | 23.8 | 0.031 | 0.115 | 0.266 |
Gemfibrozil | 2B7 | 73.6 (12.5) | 24.4 (6.2) | 0.824 | 0.332 | 0.011 | 29.7 |
Mycophenolic Acid | 1A9 | 9.32 (1.77) | 17.6 (2.4) | 1.19 | 1.89 | 0.128 | 14.8 |
Naloxone | 1A8/2B7 | 2.22 (0.17) | 0.675 (0.082) | 0.292 | 0.304 | 0.131 | 2.31 |
Propofol | 1A9 | 8.05 (0.46) | 13.1 (1.66) | 2.13 | 1.63 | 0.264 | 6.16 |
Telmisartan | 1A3 | 15.8 (2.3) | 0.439 (0.222) | 1.88 | 0.028 | 0.119 | 0.233 |