Species | Km | Vmax | CLint | Ki |
---|---|---|---|---|
mM | mM | |||
Human | ||||
AADAC | 0.2 ± 0.0 | 149.0 ± 9.0a | 0.9 ± 0.1b | 0.3 ± 0.1 |
Liver | 0.4 ± 0.0 | 272.6 ± 38.5c | 0.7 ± 0.0d | 0.2 ± 0.0 |
Jejunum | 0.3 ± 0.0 | 211.8 ± 7.4c | 0.7 ± 0.0d | 0.7 ± 0.0 |
Kidney | N.D. | N.D. | N.D. | |
Lung | N.D. | N.D. | N.D. | |
Rat | ||||
AADAC | N.D. | N.D. | N.D. | |
Liver | N.A. | N.A. | 0.0 ± 0.0d,e | |
Jejunum | N.A. | N.A. | 0.0 ± 0.0d,e | |
Kidney | N.A. | N.A. | 0.0 ± 0.0d,e | |
Lung | N.A. | N.A. | 0.0 ± 0.0d,e | |
Mouse | ||||
AADAC | N.D. | N.D. | N.D. | |
Liver | N.A. | N.A. | 0.2 ± 0.0d,e | |
Jejunum | N.D. | N.D. | N.D. | |
Kidney | N.D. | N.D. | N.D. | |
Lung | N.D. | N.D. | N.D. |
N.D., not detected; N.A., not applicable.
↵a Vmax for AADAC is measured in pmol · min−1 · unit−1.
↵b CLint for AADAC is measured in μl · min−1 · unit−1.
↵c Vmax for liver, jejunum, kidney, and lungs is measured in pmol · min−1 · mg−1.
↵d CLint for liver, jejunum, kidney, and lung is measured in μl · min−1 · mg−1.
↵e If the Km value was relatively high, the CLint value was calculated with initial slope of the velocity versus substrate concentration.