TABLE 3

Relative abundance of XMEs, transporters, nuclear receptors, and transcription factors whose expression levels vary in ileum or along the colon

Percentages are expressed compared with transverse colon expression value [for each gene transverse colon expression is baseline (= 100%)].

Assay Identification Number	Gene Name	Expression Value^{^a} in TC	I	CA	CD	R
			%
Phase I enzymes
Hs00175631_m1	ABP1	2384	191	84	93	96
Hs00605175_m1	ADH1B	224	87	77	95	180
Hs00817827_m1	ADH1C	2688	39	88	55	53
Hs00923466_m1	ADH4	9	140	99	82	70
Hs00605185_m1	ADH5	123	131	82	83	86
Hs00167423_m1	ADH6	70	138	84	67	42
Hs00329084_m1	ADHFE1	30	73	59	99	108
Hs00195992_m1	AKR1A1	660	214	92	89	94
Hs00252524_m1	AKR1B10	1400	191	103	58	32
Hs00413886_m1	AKR1C1; AKR1C2	52	73	74	68	58
Hs00366267_m1	AKR1C3	1091	187	112	69	48
Hs00230170_m1	AKR1E2	55	51	67	106	65
Hs00761005_s1	AKR7A2	181	129	107	85	115
Hs00792041_gH	AKR7A3	909	207	87	68	56
Hs00292269_m1	ALDH16A1	3	82	70	N.D.	105
Hs00913261_m1	ALDH18A1	1415	92	76	95	57
Hs00167445_m1	ALDH1A1	380	217	111	71	59
Hs00167476_m1	ALDH1A3	32	260	49	78	109
Hs00377718_m1	ALDH1B1	160	70	94	87	65
Hs00201836_m1	ALDH1L1	137	26	64	35	23
Hs00355914_m1	ALDH2	2059	112	106	71	60
Hs00964880_m1	ALDH3A1	76	31	114	39	47
Hs00166066_m1	ALDH3A2	1078	107	90	65	62
Hs00167488_m1	ALDH3B1	82	302	99	80	103
Hs00186689_m1	ALDH4A1	38	74	116	70	76
Hs00153566_m1	ALDH5A1	55	129	73	68	86
Hs00194421_m1	ALDH6A1	364	108	92	67	69
Hs00609622_m1	ALDH7A1	410	71	81	69	59
Hs00355924_m1	ALDH9A1	420	125	86	75	83
Hs00186647_m1	AOC3	77	85	67	111	173
Hs00154079_m1	AOX1	3	147	106	162	201
Hs00163746_m1	BCHE	5	134	40	97	155
Hs00156323_m1	CBR1	231	411	133	70	71
Hs00275607_m1	CES1	67	77	100	60	72
Hs00187279_m1	CES2	3486	203	78	84	93
Hs00227775_m1	CES3	1100	64	72	82	72
Hs00164383_m1	CYP1B1	19	71	32	62	32
Hs00219866_m1	CYP26B1	12	112	216	59	53
Hs01026016_m1	CYP27A1	383	137	57	65	60
Hs03044634_m1	CYP2B6	363	110	70	26	11
Hs01595322_mH	CYP2C18	171	519	155	52	17
Hs00426380_m1	CYP2C19	19	658	147	73	9
Hs00426397_m1	CYP2C9	17	1351	132	56	N.D.
Hs00559370_m1	CYP2E1	3	N.D.	59	108	94
Hs00951113_m1	CYP2J2	264	354	86	89	129
Hs01379776_m1	CYP2R1	64	127	89	122	101
Hs00258076_m1	CYP2S1	212	171	74	107	144
Hs00766273_m1	CYP2U1	36	321	75	92	111
Hs00214994_m1	CYP2W1	3	N.D.	N.D.	209	1426
Hs00213201_m1	CYP39A1	11	120	80	167	287
Hs00430021_m1	CYP3A4	4	11292	74	639	932
Hs00241417_m1	CYP3A5	172	156	42	76	79
Hs01680107_m1	CYP4F11	4	566	66	100	323
Hs00430602_g1	CYP4F12	188	110	100	88	54
Hs00426608_m1	CYP4F2	56	1510	54	52	30
Hs01389878_m1	CYP4V2	64	299	101	115	133
Hs00380077_m1	CYP4X1	3	115	108	90	135
Hs00426415_m1	CYP51A1	325	122	108	74	106
Hs00191385_m1	CYP7B1	14	62	57	86	152
Hs00949075_m1	DHRS4	235	223	100	95	88
Hs00608375_m1	DHRS9	1529	19	116	59	31
Hs00559279_m1	DPYD	141	173	74	86	86
Hs01116807_m1	EPHX1	434	71	63	63	70
Hs00157403_m1	EPHX2	581	213	101	80	89
Hs00382667_m1	ESD	330	73	85	83	84
Hs00157614_m1	FMO4	73	117	80	61	53
Hs00356233_m1	FMO5	809	151	76	94	110
Hs00400708_m1	KDM1B	390	63	70	78	81
Hs00165140_m1	MAOA	4777	160	88	78	85
Hs00168533_m1	MAOB	94	567	80	78	69
Hs00168547_m1	NQO1	1382	38	81	50	29
Hs00168552_m1	NQO2	43	120	48	117	93
Hs00382210_m1	PAOX	28	168	96	71	47
Hs00165563_m1	PON2	604	90	70	89	103
Hs00412993_m1	PON3	7	232	123	133	156
Hs00919949_m1	PTGIS	9	86	73	87	208
Hs00268403_m1	SPR	398	62	75	76	85
Hs00166578_m1	SUOX	111	73	102	72	62
Hs00233423_m1	TBXAS1	114	87	74	80	115
Hs00166010_m1	XDH	408	259	97	97	154
Phase II enzymes
Hs00221125_m1	AS3MT	12	95	56	103	101
Hs00980756_m1	GGT1	177	265	119	111	122
Hs00275575_m1	GSTA1	63	3268	127	115	151
Hs00155308_m1	GSTA4	46	118	87	94	175
Hs02341469_m1	GSTM1	7	44	N.D.	51	39
Hs00168307_m1	GSTM3	51	136	97	87	97
Hs00426432_m1	GSTM4	216	164	88	73	73
Hs00757076_m1	GSTM5	20	72	44	94	114
Hs00818731_m1	GSTO1	258	177	97	95	106
Hs00826661_m1	GSTO2	40	76	66	71	77
Hs00168310_m1	GSTP1	4243	79	80	73	82
Hs00184475_m1	GSTT1	21	89	100	67	954
Hs00199373_m1	HNMT	698	49	72	78	56
Hs00198941_m1	INMT	5	181	75	172	280
Hs00220393_m1	MGST1	3534	53	95	68	40
Hs00182064_m1	MGST2	739	129	86	80	96
Hs01058946_m1	MGST3	2578	102	87	75	62
Hs00560401_m1	MPST	2249	128	104	83	60
Hs00377717_m1	NAT1	3	73	86	80	N.D.
Hs00605099_m1	NAT2	54	123	96	95	51
Hs02340929_g1	SULT1A2	215	175	90	85	56
Hs00413970_m1	SULT1A3; SULT1A4	25	133	96	154	68
Hs00234899_m1	SULT1B1	1190	97	66	73	58
Hs00169044_m1	SULT1C2	1	232	156	353	1976
Hs00198159_m1	SULT1C4	3	295	134	296	307
Hs00190268_m1	SULT2B1	30	502	111	43	18
Hs00361812_m1	TST	2719	60	94	64	56
Hs02511055_s1	UGT1A1	261	378	39	62	36
Hs02516990_s1	UGT1A10	2279	71	82	57	35
Hs01655285_s1	UGT1A4	33	96	58	83	39
Hs01374521_s1	UGT1A5	32	122	51	72	34
Hs01592477_m1	UGT1A6	7	212	90	70	51
Hs02517015_s1	UGT1A7	242	39	45	78	42
Hs01592482_m1	UGT1A8	1043	72	88	68	35
Hs02516855_sH	UGT1A9	91	47	47	75	41
Hs00226904_m1	UGT2A3	813	183	84	75	74
Hs02556282_s1	UGT2B10	6	19	29	95	37
Hs01894900_gH	UGT2B11	4	152	121	152	70
Hs00854486_sH	UGT2B17	9575	112	102	59	24
Hs00426592_m1	UGT2B7	19	654	65	187	167
Transporters
Hs01059122_m1	ABCA1	385	37	65	73	62
Hs00242232_m1	ABCA2	43	74	69	86	105
Hs00975530_m1	ABCA3	12	182	91	134	169
Hs01105117_m1	ABCA7	40	86	114	100	65
Hs00992371_m1	ABCA8	138	64	62	98	109
Hs00184491_m1	ABCB1	175	217	44	96	90
Hs01085315_m1	ABCB10	213	118	82	85	69
Hs00184824_m1	ABCB11	122	<5	25	31	8
Hs00240956_m1	ABCB4	7	135	76	128	128
Hs00180568_m1	ABCB6	69	151	92	85	76
Hs00608640_m1	ABCB9	35	100	85	71	40
Hs00219905_m1	ABCC1	64	78	86	61	62
Hs00375716_m1	ABCC10	67	146	106	117	97
Hs00358656_m1	ABCC3	637	62	84	71	61
Hs00195260_m1	ABCC4	111	51	49	87	72
Hs00981089_m1	ABCC5	42	73	92	100	108
Hs00184566_m1	ABCC6	39	339	109	148	128
Hs00245340_m1	ABCD4	98	140	83	93	88
Hs01053787_m1	ABCG2	1030	152	64	75	39
Hs02880035_m1	ABCG8	4	1403	109	52	N.D.
Hs00166067_m1	AQP1	111	360	80	93	180
Hs00163707_m1	ATP7A	34	105	72	98	106
Hs00245438_m1	MVP	2642	155	127	117	100
Hs00166561_m1	SLC10A2	5	8539	21	37	N.D.
Hs00192639_m1	SLC15A1	14	2612	35	237	684
Hs00221539_m1	SLC15A2	15	80	98	113	369
Hs00161826_m1	SLC16A1	2611	20	84	53	22
Hs00161858_m1	SLC18A2	10	105	62	99	85
Hs00953345_m1	SLC19A1	124	149	66	70	32
Hs00949693_m1	SLC19A2	58	75	72	133	87
Hs00375596_m1	SLC19A3	57	76	63	87	55
Hs00188172_m1	SLC1A1	432	251	93	81	36
Hs00188193_m1	SLC1A3	11	48	65	107	142
Hs00427554_m1	SLC22A1	3	34	80	112	N.D.
Hs00222691_m1	SLC22A3	3	175	164	N.D.	N.D.
Hs00268200_m1	SLC22A4	20	335	61	123	138
Hs00929869_m1	SLC22A5	379	91	82	70	56
Hs00185185_m1	SLC25A13	300	78	89	71	69
Hs00188407_m1	SLC28A2	29	2868	111	137	1050
Hs00223220_m1	SLC28A3	2	150	26	N.D.	287
Hs01085706_m1	SLC29A1	56	83	84	89	125
Hs00155426_m1	SLC29A2	26	45	97	87	108
Hs00983219_m1	SLC29A3	56	64	90	62	100
Hs00542001_m1	SLC29A4	21	171	68	119	193
Hs00197884_m1	SLC2A1	198	45	95	68	108
Hs00977268_g1	SLC31A1	505	153	70	68	90
Hs01562168_m1	SLC38A1	1979	50	83	65	79
Hs01012028_m1	SLC38A5	125	45	71	86	85
Hs00165789_m1	SLC3A1	167	284	66	99	19
Hs00374243_m1	SLC3A2	336	112	66	83	86
Hs00217320_m1	SLC47A1	20	73	79	80	71
Hs00169010_m1	SLC6A4	25	1608	75	23	N.D.
Hs00204928_m1	SLC7A11	17	61	66	79	141
Hs00185826_m1	SLC7A5	17	130	158	63	77
Hs00909952_m1	SLC7A7	41	675	74	105	74
Hs00794796_m1	SLC7A8	188	120	65	77	122
Hs00200670_m1	SLCO2B1	194	126	70	76	73
Hs00203184_m1	SLCO3A1	27	59	67	80	125
Hs00249583_m1	SLCO4A1	36	73	84	124	123
Hs00698884_m1	SLCO4C1	11	202	111	95	98
Hs00229597_m1	SLCO5A1	22	63	70	97	131
Hs00388682_m1	TAP1	788	117	94	89	72
Hs00241060_m1	TAP2	190	145	81	96	85
Nuclear receptors and transcription factors
Hs00610222_m1	AIP	281	97	70	78	63
Hs00208298_m1	ARNT2	16	148	75	130	157
Hs00231733_m1	CREBBP	530	98	60	84	91
Hs00230938_m1	EP300	622	90	64	77	84
Hs00230957_m1	ESR2	11	36	101	59	75
Hs00232764_m1	FOXA2	52	55	61	114	259
Hs01054576_m1	FOXO1	127	76	65	69	89
Hs00541709_m1	HIF3A	7	91	94	187	232
Hs00604435_m1	HNF4A	2650	92	77	82	73
Hs00743767_sH	HSP90AA1	2627	126	98	91	83
Hs00186661_m1	NCOA1	655	119	61	86	104
Hs00896106_m1	NCOA2	170	119	75	87	101
Hs00196955_m1	NCOR2	212	98	74	108	110
Hs00222677_m1	NR0B2	4	2231	87	117	238
Hs00173195_m1	NR1H2	71	144	102	101	95
Hs00172885_m1	NR1H3	137	104	78	66	43
Hs00231968_m1	NR1H4	115	546	179	56	10
Hs00243666_m1	NR1I2	576	114	75	89	53
Hs00353740_m1	NR3C1	122	216	90	118	142
Hs01031809_m1	NR3C2	431	85	70	97	89
Hs00187067_m1	NR5A2	452	138	73	96	98
Hs00231882_m1	PPARA	97	119	91	69	78
Hs00602622_m1	PPARD	536	58	127	87	76
Hs01115513_m1	PPARG	998	37	89	75	41
Hs00173304_m1	PPARGC1A	198	65	59	89	83
Hs00370186_m1	PPARGC1B	184	72	93	74	114
Hs00209379_m1	PPRC1	81	61	75	83	96
Hs00940446_m1	RARA	162	153	100	87	83
Hs00233407_m1	RARB	23	80	78	47	50
Hs01559234_m1	RARG	50	60	98	117	171
Hs01067640_m1	RXRA	1352	76	84	77	65
Hs00232774_m1	RXRB	155	133	104	100	105
Hs00199455_m1	RXRG	13	105	59	93	121
Hs00268470_m1	THRA	287	116	81	75	79
Hs00230861_m1	THRB	160	25	18	139	128
Hs01045840_m1	VDR	1651	81	71	78	81
Other genes
Hs00171635_m1	CRABP1	7	151	43	110	74
Hs00275636_m1	CRABP2	3	94	90	210	130
Hs00196206_m1	GZMA	134	90	52	63	41
Hs00188051_m1	GZMB	7	78	98	64	47
Hs00831826_s1	MT1A	49	127	32	115	150
Hs00744661_sH	MT1F	496	150	66	107	98
Hs00823168_g1	MT1H	6	101	34	75	107
Hs00828387_g1	MT1M	280	111	38	145	166
Hs00745167_sH	MT1X	1606	98	52	78	71
Hs02379661_g1	MT2A	487	106	49	91	98
Hs00359394_g1	MT3	6	51	146	149	125
Hs00287016_m1	POR	595	173	81	81	73
Hs00161252_m1	RBP1	46	80	74	53	53
Hs00188160_m1	RBP2	7	9275	130	116	114
Hs00153349_m1	TP53	197	63	75	68	97
Hs00828652_m1	TXN	3791	70	82	105	103

I, ileum; AC, ascending colon; TC, transverse colon; DC, descending colon; R, rectum; N.D., not detected.
↵a Expression value is a relative number calculated on the basis of the assumption that the average expression level of two housekeeping genes RPLP0 and PPIA is 10,000 copies.