TABLE 1

Summary of seven radioactive components of [¹⁴C]lenvatinib after oral administration to male cynomolgus monkey at 30 mg/kg

	Retention Time	Proposed Formula	Calculated [M+H]⁺	Observed [M+H]⁺	Error	Product Ions	Bile	Urine	Plasma	Liver
	min		m/z	m/z	ppm	m/z
C1	12.2	C₁₃H₁₃N₂O₄S⁺	293.0591	293.0593	0.7	234, 216, 161		Y
C2	13.1	C₂₁H₂₆N₅O₈S⁺	508.1497	508.1501	0.8	379, 235, 218				Y
C3	13.5	C₂₈H₂₉N₆O₈S₂⁺	641.1483	641.1496	2.0	354, 288, 244	Y	Y
C4	14.1	C₃₀H₃₂N₇O₉S₂⁺	698.1697	698.1694	0.4	411, 244		Y
C5	14.5	C₁₄H₁₆N₃O₄S⁺	322.0856	322.0864	2.5	276, 244, 218	Y			Y
C6	17.1	C₂₅H₂₄N₅O₆S⁺	522.1442	522.1436	1.1	505, 244	Y	Y		Y
C7	46.4	C₂₁H₂₀ClN₄O₄⁺	427.1168	427.1169	0.2	370, 353, 327	Y		Y	Y