TABLE 2
Percentage of identified metabolites in hepatocytes
Metabolite
Krebs' Buffer
Human
Dog
Rat
%
radioactivity
M2
0.5
25.5
8.7
M4
44.8
10.2
M6
3.5
4.4
1.0
0.3
M7
49.0
3.0
37.5
M10
1.7
0.4
0.4
M11
11.1
M13
2.0
4.4
M14
7.0
M15
3.4
M16
1.9
M17
1.8
3.0
9.1
M18
9.0
13.1
BIIB021
96.5
38
0.8
5.2