TABLE 2
Summary of proton NMR chemical shifts for lenvatinib, C1, C3, and C4
| Position | δH (Integration, Multiplicity, J) | |||
|---|---|---|---|---|
| Lenvatinib | C1 | C3 | C4 | |
| 1 | 8.85 (1 H, d, J = 7 Hz) | 8.58 (1 H, d, J = 5 Hz) | 8.16 (2 H, d, J = 7 Hz) | 8.26 (1 H, d, J = 6 Hz) |
| 2 | 6.98 (1 H, d, J = 7 Hz) | 7.32 (1 H, d, J = 5 Hz) | 6.54 (2 H, d, J = 7 Hz) | 6.62 (1 H, d, J = 6 Hz) |
| 3 | 9.01 (1 H, s) | 8.79 (1 H, s) | 8.74 (2 H, s) | 8.81 (1 H, s) |
| 4 | 7.57 (1 H, s) | 7.45 (1 H, s) | 7.08 (2 H, s) | 7.17 (1 H, s) |
| 5 | 4.19 (3 H, s) | 4.07 (3 H, s) | 4.04 (6 H, s) | 4.06 (3 H, s) |
| 6 | 7.52 (1 H, d, J = 2 Hz) | 3.84 (2 H, s) | 4.47 (2 H, dd, J = 9.5 Hz) | 4.73 (1 H, dd, J = 8.5 Hz) |
| 7 | 8.30 (1 H, d, J = 9 Hz) | 3.51 (2 H, dd, J = 14.5 Hz, Ha), 3.22 (2 H, dd, J = 14.9 Hz, Hb) | 3.56 (1 H, dd, J = 14.5 Hz, Ha), 3.19 (1 H, dd, J = 14.9 Hz, Hb) | |
| 8 | 7.30 (1 H, dd, J = 9.2 Hz) | 3.81 (1 H, d, J = 17 Hz, Ha), 3.68 (1 H, d, J = 17 Hz, Hb) | ||
| 9 | 2.63 (1 H, m) | |||
| 10 | 0.78 (1 H, m, Ha), 0.55 (1 H, m, Hb) | |||
| 11 | 0.78 (1 H, m, Ha), 0.55 (1 H, m, Hb) | |||
| 1′ | 8.19 (1 H, d, J = 7 Hz) | |||
| 2′ | 6.62 (1 H, d, J = 7 Hz) | |||
| 3′ | 8.76 (1 H, s) | |||
| 4′ | 7.08 (1 H, s) | |||
| 5′ | 4.06 (3 H, s) | |||
| 6′ | 4.54 (1 H, m) | |||
| 7′ | 3.58 (1 H, dd, J = 13.5 Hz, Ha), 3.28 (1 H, m, Hb) | |||
Multiplicities are reported as follows: s, singlet; d, doublet; dd, doublet of doublet; m, multiplet.
