TABLE 2

Dantrolene AUC changes in wild-type mice predosed intravenously with vehicles or inhibitors

Dantrolene blood, brain, and CSF AUC in wild-type mice in the absence and presence of the inhibitors were determined, and AUC ratios were calculated.

AUC RatioKo143PSC833GF120918
AUCblood, I/C1.010.840.96
AUCbrain, I/C2.191.062.07
AUCCSF, I/C2.371.152.56
AUCbrain/blood, I/C2.171.262.12
AUCCSF/blood, I/C2.351.362.62
AUCCSF/brain, I/C1.081.081.24

  • I, inhibitor; C, control.