Kinetic parameters of 4′-hydroxyflurbiprofen formation with pooled, HH519, and HL9310 human liver microsomes
Data were fit to the Michaelis-Menten equation and are presented as mean ± S.E. of the fit.
| HLM Sample | CYP2C9 Genotype | Vmax | Km | Vmax/Km |
|---|---|---|---|---|
| pmol · min−1 · mg protein−1 | μM | |||
| Pooled | *1/*1 | 856 ± 10 | 5 ± 0.3 | 171 |
| HH519 | *3/*3 | 167 ± 4*** | 17 ± 2* | 10 |
| HL9310 | *3/*3 | 49 ± 3*** | 24 ± 6* | 2 |