TABLE 1

Physicochemical and in vitro properties for the compounds studied

Compound	Log D_7.4	Charge^{^a}	pK_a	B/P	fu, p	HLM CL_{int, u, met}
						μl · min⁻¹ · mg⁻¹
Pravastatin	−0.84	A	4.6	0.55	0.43	0
Cerivastatin	1.8	Z	5.3 (B); 5.0 (A)	0.76	0.0048	29
Bosentan	1.3	A	5.2	0.48	0.0053	22^{^b}
Fluvastatin	1.6	A	4.6	0.57	0.0041	76
Rosuvastatin	−0.33	A	4.2	0.56	0.094	0
Valsartan	−0.88	A	3.8; 4.6	0.55	0.0010	0
Repaglinide	2.1	Z	6.1 (B); 4.4 (A)	0.48	0.0074	128^{^c}