TABLE 4

Predicted CL and V_ss parameters for the seven drugs investigated using different modeling scenarios

Compound	CL			V_ss
Compound	Clinical^{^a}	In Vitro-Scaled^{^b}	In Vitro-Scaled + Scaling Factor	Clinical^{^a}	In Vitro-Scaled^{^b}	In Vitro-Scaled + Scaling Factor
	ml · min⁻¹ · kg⁻¹			l/kg
Pravastatin	14	8.0	17	0.46	0.20	0.36
Cerivastatin	2.9	0.17	2.0	0.33	0.15	0.21
Bosentan	2.3	0.14	3.5	0.67	0.12	0.17
Fluvastatin	8.7	0.46	8.1	0.16	0.13	0.16
Rosuvastatin	11	4.0	7.6	1.7	0.15	1.5
Valsartan	0.49	0.15	0.42	0.23	0.11	0.12
Repaglinide	7.8	0.74	6.4	0.35	0.15	0.16
Absolute average fold error		7.1	1.3		3.0	1.7

↵a Reported intravenous CL and V_ss parameters from publications reported in Supplemental Table S1.
↵b Predicted intravenous CL and V_ss parameters determined by noncompartmental analysis of predicted profiles.