TABLE 4

Minor allele frequency of CYP2C9 *3, *2 and promoter pVNTR alleles

The LD r² refers to the pVNTR-S and *3, determined in different cohorts. The LD r² between *2 and pVNTR-S is zero in all cohorts. The SMX cohort was used in another study in which patients were taking SMX as described under Materials and Methods.

Individuals	Minor Allele Frequency					Number	LD r²
Individuals	*3	*2	pVNTR-S	pVNTR-M	pVNTR-L	Number	LD r²
Caucasian
Liver cohort	0.048	0.154	0.062	0.778	0.160	146	0.76
SMX cohort	0.052	0.145	0.054	0.799	0.147	334	0.69
Warfarin cohort	0.048	0.120	0.062	0.777	0.161	324	0.79
Combined	0.050	0.137	0.058	0.789	0.152	804	0.75
Black
SMX cohort	0.031	0.036	0.052	0.784	0.164	96	0.58
Warfarin cohort	0	0.042	0.045	0.954	0	24	N.A.
Combined	0.025	0.038	0.051	0.883	0.065	120	0.53
Egyptian cohort	0.092	0.112	0.115	0.780	0.100	207	0.59

N.A., not applicable.