PK parameters of PEG30-EPO and PEG40-EPO in the thoracic LDC and control SD rats after subcutaneous administration
| Parameter | PEG30-EPO (CERA) | PEG40-EPO | ||
|---|---|---|---|---|
| LDC (n = 6) | Control (n = 3) | LDC (n = 3) | Control (n = 3) | |
| AUC0–168 h, h · ng/ml | 2221 ± 1208 | 8356 ± 1446 | 1188 ± 213 | 5013 ± 3635 |
| Cmax, ng/ml | 37.5 ± 17.8 | 113.7 ± 30.0 | 26.6 ± 6.0 | 85.1 ± 41.9 |
| F, % | 10 | 38 | 10 | 30 |
| Cumulative recovery_lymph, post-TCA, % dose | 23.8 ± 3.5 | 13.7 ± 4.8 | ||
| Cumulative recovery_lymph, pre-TCA, % dose | 31.1 ± 3.7 | 21.1 ± 4.5 | ||
| Cumulative recovery_urine, pre-TCA, % dose | 38.2 ± 4.2 | 75.7 ± 12.5 | N.D. | N.D. |
| Cumulative recovery_feces, pre-TCA, % dose | 1.6 | 2.2 | N.D. | N.D. |
| Cumulative recovery_total, pre-TCA, % dose | 71.9 | 77.9 | N.D. | N.D. |
N.D., not determined.