TABLE 1

Serum and milk protein binding for PAN isomers in lactating Sprague-Dawley rats (n = 4)

Data are presented as mean ± S.D., unpaired t test. Skim-to-whole milk partitioning ratio and diffusion model prediction of M/S (Fleishaker et al., 1987) for PAN.

Parameter	(+)PAN	(−)PAN
Fraction unbound serum, %^{^a}	2.33 ± 0.51	2.38 ± 0.74
Fraction unbound milk, %^{^a}	26.0 ± 2.7	27.1 ± 7.3
Whole to skim milk ratio^{^b}	1.33	1.3
Predicted M/S (eq. 1)	0.12	0.11

↵a Mean ± S.D. (n = 4).
↵b Single determination from a pooled sample.