Pharmacokinetic parameters for total radioactivity in plasma after oral and intravenous administration of [35S]2
Data are presented as mean ± S.D. values derived at each time point from nine male and nine female rats.
| Parameter | Intravenous Dose | Oral Dose | ||
|---|---|---|---|---|
| Male | Female | Male | Female | |
| t1/2, h | 7.8 | 9.0 | NC | NC |
| Tmax, h | NA | NA | 4 | 4 |
| Cmax, μg-Eq/ml | 6.51 ± 0.60 | 4.49 ± 0.16 | 2.53 ± 0.30 | 2.50 ± 0.22 |
| Cmaxp.o./Cmaxi.v. | NA | NA | 0.39 | 0.56 |
| AUC, h-μg-Eq/ml | 53.58 ± 1.37 | 35.21 ± 3.23 | 26.86 ± 3.52 | 27.37 ± 2.52 |
| AUCp.o./AUCi.v. | NA | NA | 0.50 | 0.78 |
NC, not calculated; NA, not applicable; AUCp.o., area under the plasma concentration-time profile with oral dose administration; AUCi.v., area under the plasma concentration-time profile with intravenous dose administration.