TABLE 4

Experiment 2: clearances, intracellular concentrations, and error obtained with the three-compartment model

Drug	CL_davg	CL_ae	Error	C_cell,ABpass	C_cell,BApass	C_cell,ABeff	C_cell,BAeff	C_cell,AB Ratio	C_cell,BA Ratio
	μl/min			μM
Atorvastatin	0.061	2.3	8.9	2.5	2.5	0.13	0.13	19	19
Digoxin	0.17	12	2	2.5	2.5	0.067	0.069	37	37
Labetalol	0.15	4.6	12	2.5	2.5	0.16	0.16	16	16
Loperamide	0.39	87	11	2.5	2.6	0.022	0.023	110	110
Minoxidil	0.078	0.16	3.3	2.5	2.5	1.2	1.2	2	2
Pitavastatin	0.15	2.8	9.1	2.5	2.5	0.24	0.24	11	10

CL_davg, arithmetic mean of CL_dAB and CL_dBA; CL_ae, apical efflux clearance; C_cell,ABpass, predicted intracellular concentration from A-B experiments with passive diffusion only (MDCK cells); C_cell,BApass, predicted intracellular concentration from B-A experiments with passive diffusion only (MDCK cells); C_cell,ABeff, predicted intracellular concentration from A-B experiments with passive diffusion plus apical efflux (MDR1-MDCK cells); C_cell,BAeff, predicted intracellular concentration from B-A experiments with passive diffusion plus apical efflux (MDR1-MDCK cells); C_cell,AB ratio, ratio of C_cell,ABpass to C_cell,ABeff; C_cell,BA ratio, ratio of C_cell,BApass to C_cell,BAeff.