TABLE 3

The fitted mean (±S.E. from nonlinear fitting) kinetic parameters (Km and Tmax) in both rAbcg2 and ABCG2

Overall permeability associated with rAbcg2/ABCG2 was calculated as the ratio of TMax over KM.

IsoformParameters(−)PAN(+)PAN
Mean (±S.E.)
rAbcg2TMax, nmol/h · cm22.49 ± 0.417.86 ± 2.20
KM, μM0.25 ± 0.061.85 ± 0.66
r20.9830.933
PSAE,Eff, (μ/h)/cm299604250
ABCG2TMax, nmol/h · cm23.29 ± 0.4810.2 ± 2.43
KM, μM0.59 ± 0.125.32 ± 1.62
r20.9840.932
PSAE,Eff, (μ/h)/cm254801920