Formation of CYP2J2-mediated metabolites of astemizole and amiodarone in various HLM preparations
| HLM | CYP2J2 Content | Astemizole Desmethylation | 4-Hydroxyamiodarone |
|---|---|---|---|
| pmol/mg | pmol−1 · min · pmol−1 CYP2J2 (mean ± S.D.) | pmol−1 · min · pmol−1 CYP2J2 (mean ± S.D.) | |
| 130 | 0.047 | 1357 ± 77 | 82 ± 2 |
| 128 | 0.165 | 254 ± 18 | 18.8 ± 0.9 |
| 118 | 0.900 | 38 ± 3 | 7.2 ± 0.2 |
| 119 | 0.567 | 172 ± 12 | 12.7 ± 0.3 |
| 153 | 0.941 | 80 ± 34 | 7.9 ± 0.1 |
| 133 | 1.578 | 39 ± 2 | 2.8 ± 0.1 |
| 149 | 0.912 | 80.7 ± 0.6 | 4.5 ± 0.2 |
| 144 | 1.131 | 77 ± 1 | 3.2 ± 0.2 |
| 109 | 2.20 | 98 ± 1 | 0.9 ± 0.2 |
| 128 | 1.20 | 196 ± 7 | 2.1 ± 0.2 |
| 159 | 2.40 | 87 ± 17 | 0.9 ± 0.1 |
| 129 | 3.50 | 93 ± 3 | 1.6 ± 0.1 |
| 146 | 7.60 | 44 ± 6 | 0.5 ± 0.0 |
| Pooled HLM | 2.59 | 32 ± 1 | 3.1 ± 0.1 |