Estimated IC50 (μM) values of commonly used drugs for hydroxylation of 1α,25-(OH)2D3 in HLM
| Inhibitors | M1 | M2 | M3 | M4 |
|---|---|---|---|---|
| Ritonavira | 0.013 (0.001–0.154) | 0.028 (0.003–0.227) | 0.008 (0.000–0.113) | 0.016 (0.002–0.151) |
| Ketoconazolea | 0.040 (0.024–0.065) | 0.042 (0.027–0.067) | 0.565 (0.162–1.971) | 0.032 (0.021–0.050) |
| Clarithromycina | >30 | >30 | >30 | >30 |
| Tamoxifena | >40 | >40 | >40 | >40 |
| Docetaxela | 0.038 (0.007–0.203) | 0.077 (0.018–0.338) | 0.012 | 0.038 (0.012–0.120) |
↵a Values represent means (95% confidence interval) of triplicate determinations.