TABLE 5

Inclusion of endogenous canine clearances in the estimation of passive and apical efflux clearances and error

Data from both experiments 1 and 2 were used.

Drug	Experiment	CL_davg	CL_bec	CL_aec	CL_ae	Error
		μl/min
Atorvastatin	1	0.078	0.074	0.12	34	25
Atorvastatin	2	0.054	0.074	0.12	6.6	10
Digoxin	1	0.28	0.5	0.01	36	2.4
Digoxin	2	0.15	0.5	0.01	11	2.2
Labetalol	1	0.066	0.019	0	9.5	27
Labetalol	2	0.15	0.019	0	4.4	12
Loperamide	1	1.1	1.5	0	210	3.3
Loperamide	2	0.38	1.5	0	82	12
Minoxidil	1	0.11	0.076	0.039	0.2	2.5
Minoxidil	2	0.073	0.076	0.039	0.19	3.5
Pitavastatin	1	0.08	0.28	0.1	9.8	33
Pitavastatin	2	0.15	0.28	0.1	4.6	8.8

CL_davg, arithmetic mean of CL_dAB and CL_dBA; CL_bec, canine basolateral efflux clearance; CL_aec, canine apical efflux clearance; CL_ae, apical efflux clearance.