TABLE 5
Deacetylase inhibitory activity of major P450 metabolites and panobinostat (nanomolar IC
50
)
HDAC Class
LBH589
M1
M2
M4
M7
HDAC1
I
2.5
140
970
11,000
4600
HDAC2
I
13
1500
6000
29,000
27,000
HDAC3
I
2.1
180
930
22,000
3300
HDAC4
IIa
200
230
1000
18,000
4600
HDAC6
IIb
11
62
1100
>30,000
4900
HDAC8
I
280
920
23,000
22,000
6800