Species | Total GDC-0973 Concentrationa | Blood-to-Plasma Ratio of [14C]GDC-0973 |
---|---|---|
μM | ||
Mouse | 1 | 1.16 ± 0.03 |
5 | 1.19 ± 0.03 | |
10 | 1.27 ± 0.02 | |
Rat | 1 | 1.36 ± 0.02 |
5 | 1.37 ± 0.02 | |
10 | 1.51 ± 0.08 | |
Dog | 1 | 0.632 ± 0.011 |
5 | 0.752 ± 0.009 | |
10 | 0.936 ± 0.011 | |
Cynomolgus monkey | 1 | 1.57 ± 0.04 |
5 | 1.64 ± 0.03 | |
10 | 1.82 ± 0.07 | |
Human | 1 | 0.933 ± 0.014 |
5 | 0.945 ± 0.007 | |
10 | 1.05 ± 0.01 |
↵a Unlabeled + [14C]-labeled GDC-0973 (free-base equivalents).