IC50 values of potential CYP2J2 inhibitors against other P450s
| Drug | IC50 (μM) | |||||
|---|---|---|---|---|---|---|
| CYP1A2 | CYP2C8 | CYP2C9 | CYP2C19 | CYP2D6 | CYP3A4 | |
| Albendazole | >30 | >30 | >30 | >30 | >30 | >30 |
| Astemizole | >30 | >30 | >30 | 13.7 | >30 | 10.6 |
| Bepridil | >30 | >30 | >30 | <0.1 | >30 | >30 |
| Clotrimazole | 1.25 | 0.803 | 0.136 | 7.41 | 0.883 | <0.1 |
| Danazol | >30 | 1.95 | 1.44 | >30 | 2.74 | >30 |
| Haloperidol | >30 | >30 | >30 | 2.87 | >30 | 8.20 |
| Isradipine | 28.3 | 5.00 | 3.66 | >30 | 4.79 | >30 |
| Ivermectin | >30 | >30 | >30 | >30 | >30 | >30 |
| Ketoconazole | 26 | 2.45 | 8.94 | 10.1 | 16.3 | <0.1 |
| Lansoprazole | 6.46 | 5.75 | 19.2 | 13.4 | 2.90 | >30 |
| Loratadine | >30 | 2.95 | >30 | 2.80 | <0.1 | >30 |
| Mefloquine | >30 | >30 | >30 | 14.9 | >30 | 0.667 |
| Nicardipine | >30 | 1.56 | 0.378 | 3.30 | 1.59 | >30 |
| Orphenadrine | >30 | >30 | >30 | 24.2 | >30 | >30 |
| Paroxetine | 5.33 | >30 | >30 | >30 | 0.96 | 24.1 |
| Pimozide | >30 | >30 | >30 | >30 | >30 | >30 |
| Quercetin | 1.55 | 1.39 | 10.2 | 10.5 | 18.8 | 2.11 |
| Simvastatin | >30 | 3.70 | >30 | >30 | >30 | >30 |
| Tamoxifen | >30 | 14.3 | >30 | >30 | 13.7 | >30 |
| Verapamil | >30 | >30 | >30 | >30 | >30 | 17.6 |