TABLE 2

Pharmacokinetic parameters (mean ± S.D.) of BMS-562086 in rats, dogs, and chimpanzees

Species	Route	Dose	C_max	T_max	AUC_(INF)	t_1/2	CL_p	V_z	F
		mg/kg	nM	h	nM · h	h	ml · min⁻¹ · kg⁻¹	l/kg	%
Rat
	i.v.	1			2900 ± 912	13.5 ± 3.1	17.9 ± 4.8	14.9 ± 1.0
	p.o.	5	1261 ± 552	0.75^{^a} (0.5, 0.75)	5815 ± 1307	13.81.8			40.1
Dog	i.v.	1			4296 ± 789	43.9 ± 8.2	11.6 ± 2.0	28.2 ± 5.6
	p.o.	5	1798 ± 516	0.75^{^a} (0.25, 1.0)	13,043 ± 6369	46.7 ± 5.1			58.8 ± 18
Chimpanzee^{^b}	i.v.	0.5			11,900	30	2.0	4.2
	p.o.	1	1070 (840, 1300)	2 (2, 2)	13,900 (11,700, 16,100)	26 (26, 26)			58.5 (49, 68)

i.v., intravenous; p.o., oral.
↵a Median (minimum, maximum).
↵b S.D. was not obtained because only two animals were used for oral administration and one animal for intravenous administration. Pharmacokinetic parameters were reported as mean (minimum, maximum) for oral administration.