TABLE 1

The observed ER_α, permeability parameters (PS_PC) of mannitol, and permeability parameters (PS_obs and PS_D) of PAN isomers transport in empty and rAbcg2-MDCKII as a function of PAN donor concentration

PS units are expressed as (μl/h)/cm².

Cell Line	Substrate/Isomer	Parameter	3 μM	10 μM	30 μM	50 μM	200 μM	Mean	S.D.
Empty-MDCKII	(−)PAN	PS_obs A→B	118	123	116	121	130	121	5
		PS_obs B→A	120	130	123	126	135	127	6
		ER_α	1.02	1.06	1.07	1.04	1.04	1.05	0.02
	(+)PAN	PS_obs A→B	116	114	110	123	142	121	13
		PS_obs B→A	117	121	116	135	140	126	11
		ER_α	1.01	1.07	1.06	1.09	0.98	1.04	0.05
	(−)/(+)PAN	PS_D	231	242	226	251	271	244	18
	Mannitol	PSpc	2.3	1.14	3.54	0.72	1.39	1.82	1.12
rAbcg2-MDCKII	(−)PAN	PS_obs A→B	7.4	30.1	92.5	109	127	N.A.	N.A.
		PS_obs B→A	253	224	151	137	136	N.A.	N.A.
		ER_α	34	7.44	1.63	1.26	1.07	N.A.	N.A.
	(+)PAN	PS_obs A→B	12.8	20.9	33.5	79.1	126	N.A.	N.A.
		PS_obs B→A	238	229	206	194	162	N.A.	N.A.
		ER_α	18.7	11	6.16	2.46	1.29	N.A.	N.A.
	Mannitol	PS_PC	0.51	0.88	3.44	0.72	1.59	1.43	1.2

N.A., not applicable.