M1 | M2 | M3 | M4 | M5 | M6 | M7 | M8 | LBH589 | |
---|---|---|---|---|---|---|---|---|---|
rh P450s in E. coli | |||||||||
Host strain JM109 | 1.2 | 1.2 | 43 | 55 | |||||
CYP1A1 | 2.5 | 1.9 | 34 | 0.2 | 0.7 | 0.1 | 61 | ||
CYP1A2 | 1.5 | 0.5 | 23 | 0.2 | 1.4 | 0.7 | 72 | ||
CYP1B1 | 2.1 | 0.6 | 19 | 0.1 | 79 | ||||
CYP2A6 | 9.0 | 0.8 | 0.2 | 8 | 1.4 | 81 | |||
CYP2B6 | 2.1 | 1.4 | 35 | 62 | |||||
CYP2C8 | 1.7 | 1.2 | 34 | 63 | |||||
CYP2C9 | 1.3 | 3.1 | 61 | 0.1 | 0.5 | 34 | |||
CYP2C18 | 3.2 | 2.6 | 38 | 0.1 | 56 | ||||
CYP2C19 | 3.9 | 0.6 | 11 | 0.1 | 2.9 | 0.9 | 0.1 | 80 | |
CYP2D6 | 1.3 | 1.2 | 0.1 | 33 | 2.4 | 3.7 | 13.4 | 0.3 | 44 |
CYP2E1 | 2.1 | 2.4 | 46 | 0.1 | 50 | ||||
CYP3A4 | 7.8 | 12.8 | 0.2 | 40 | 1.3 | 37 | |||
CYP3A4 + Cyt b5a | 31.9 | 7.6 | 1.6 | 5 | 8.5 | 45 | |||
CYP3A5 | 7.1 | 1.7 | 0.1 | 17 | 0.8 | 73 | |||
CYP4A11 | 2.0 | 1.5 | 37 | 59 | |||||
rh P450s in Supersomes | |||||||||
CYP3A4 | 6.1 | 94 | |||||||
CYP2D6 | 0.8 | 5.6 | 94 |
↵a Cyt b5, Cytochrome b5 (Voice et al., 1999).