TABLE 1

Percentage of uncorrected peak areas of panobinostat (LBH589) and metabolites after exposure to rh P450s for 1 h (diode array detection at 280 nm)

	M1	M2	M3	M4	M5	M6	M7	M8	LBH589
rh P450s in E. coli
Host strain JM109	1.2	1.2		43					55
CYP1A1	2.5	1.9		34	0.2		0.7	0.1	61
CYP1A2	1.5	0.5		23	0.2	1.4	0.7		72
CYP1B1	2.1	0.6		19	0.1				79
CYP2A6	9.0	0.8	0.2	8	1.4				81
CYP2B6	2.1	1.4		35					62
CYP2C8	1.7	1.2		34					63
CYP2C9	1.3	3.1		61	0.1		0.5		34
CYP2C18	3.2	2.6		38	0.1				56
CYP2C19	3.9	0.6		11	0.1	2.9	0.9	0.1	80
CYP2D6	1.3	1.2	0.1	33	2.4	3.7	13.4	0.3	44
CYP2E1	2.1	2.4		46	0.1				50
CYP3A4	7.8	12.8	0.2	40	1.3				37
CYP3A4 + Cyt b₅^{^a}	31.9	7.6	1.6	5	8.5				45
CYP3A5	7.1	1.7	0.1	17	0.8				73
CYP4A11	2.0	1.5		37					59
rh P450s in Supersomes
CYP3A4	6.1								94
CYP2D6	0.8					5.6			94