TABLE 2

Pharmacokinetic parameters of GLB after oral administration (10 mg/kg) to CON, DM, and DM+IN rats

Data represent the mean ± S.D. for six or seven rats.

Parameter	CON	DM	DM+IN
AUC_0–∞, μg-h/ml	2.61 ± 0.44	15.23 ± 4.79^**	3.00 ± 1.41^{^##}
AUC_0–t, μg-h/ml	2.35 ± 0.29	13.27 ± 3.94^**	2.38 ± 0.96^{^##}
t_1/2, h	4.55 ± 1.23	5.11 ± 1.08	8.18 ± 6.43
Mean residence time, h	7.23 ± 1.70	9.28 ± 1.57	8.15 ± 2.30
CL/F, l · h⁻¹ · kg⁻¹	3.93 ± 0.68	0.72 ± 0.26^**	3.98 ± 1.76^{^##}
V_d/F, l/kg	25.72 ± 8.84	6.36 ± 0.63^**	36.8 ± 17.10^{^##}
C_max, μg/ml	0.35 ± 0.11	1.25 ± 0.24^**	0.25 ± 0.06^{^##}
Time to reach C_max, h	1.50 ± 1.00	7.2 ± 1.79^**	1.0 ± 0.61^{^##}
Biliary excretion, % of dose	0.01 ± 0.007	0.097 ± 0.130	0.018 ± 0.017
Urinary excretion, % of dose	0.0042 ± 0.001	0.023 ± 0.009^**	0.019 ± 0.005^{^##}
Fecal excretion, % of dose	72 ± 10	40 ± 9^**	50 ± 21^{^#}