TABLE 1

Michaelis-Menten kinetic parameters for BILR 355 metabolism as measured by compound depletion in human liver microsomes (n = 2)

HLM Lot	Testosterone 6β-Hydroxylase Activities	HLM Protein Conc.	Apparent K_m	V_max	CL_{int, in vitro}	CL_{int, in vivo}	CL_h	CL_h/Q_h
	nmol · min⁻¹ · mg⁻¹	mg/ml	μM	pmol · min⁻¹ · mg⁻¹ HLM protein	ml · min⁻¹ · mg⁻¹ HLM protein	ml · min⁻¹ · kg⁻¹ b.wt.		%
1028	0.7	2	0.73	46.5	0.0637	73.7	16.2	78.1
1013	1.8	2	1.14	35.0	0.0307	35.5	13.1	63.2
1008	4.6	1	0.64	133	0.208	240	19.1	92.1
1003	7.9	0.5	0.63	230	0.365	422	19.7	95.3
Mean ± S.D.			0.79 ± 0.24	111 ± 91	0.167 ± 0.153	193 ± 177	17.0 ± 3.0	82.2 ± 14.7