TABLE 3

Excretion of metabolites in bile, urine, and feces 0 to 48 h after 25 mg of free base/kg oral dose of [¹⁴C]P to male and female BDC rats

Trace amounts were detected in LC-MS analyses but not radiochromatograms.

	M_r	Male				Female
	M_r	Bile	Urine	Feces	Total	Bile	Urine	Feces	Total
		% of dosed radioactivity
P	487	co w M3	<0.1	Trace	co w M3	1.0	0.2	Trace	1.2
M1	389	9.1	3.5	53.1	65.7	8.6	9.3	51.0	68.9
M2	365	5.7^{^a}		1.0	6.7	4.8^{^a}	0.3	1.1	6.2
M3	364	<1.3	co w P	0.3	<1.6		0.1	0.8	0.9
M6	461	co w M18			co w M18	co w M18			co w M18
M7a	381		0.2		0.2		0.2		0.2
M7b	381	0.8	0.2		1.0	0.4	0.3		0.7
M8	396		0.4		0.4		0.5		0.5
M9	515	0.7^{^a}			0.7	0.4^{^a}			0.4
M10	476	1.0			1.0	0.8			0.8
M11	418	1.2			1.2	0.3			0.3
M12	504	0.3			0.3	0.1			0.1
M13	600	1.0			1.0	0.5			0.5
M14	657	0.2			0.2	0.1			0.1
M15	501					co w M18			co w M18
M16a	405	0.8	0.2		1.0	0.7	0.3		1.0
M16b	405	0.6	0.1		0.7	0.3	0.2		0.5
M17a/M17b/M17c	541	3.7			3.7	1.5			1.5
M18	418	<0.5			<0.5	<0.6			<0.6
M19	535		0.3		0.3		0.3		0.3

co w, coeluted with.
↵a The percentages of coeluted M2 and M9 were determined by using results acquired with another LC method that separated M2 and M9.