P450 | Activity | IC50 (CV) | |
---|---|---|---|
Direct | TDI | ||
μM | |||
CYP1A2 | Phenacetin O-deethylase | 7.6 (22%) | 1.1 (8%) |
CYP2A6 | Coumarin 7-hydroxylase | N.A. | N.A. |
CYP2B6 | Bupropion hydroxylase | >50 | ∼50 |
CYP2C8 | Paclitaxel 6α-hydroxylase | N.A. | N.A. |
CYP2C9 | Tolbutamide methylhydroxylase | >50 | >50 |
CYP2C19 | (S)-Mephenytoin 4-hydroxylase | 40 (18%) | 38 (13%) |
CYP2D6 | Dextromethorphan O-demethylase | >50 | >50 |
CYP2E1 | Chlorzoxazone 6-hydroxylase | N.A. | N.A. |
CYP3A4/5 | Nifedipine oxidase | N.A. | N.A. |
CYP3A4/5 | Midazolam 1-hydroxylase | >50 | ∼50 |
CYP3A4/5 | Testosterone 6β-hydroxylase | ∼50 | 44 (9%) |
CV, coefficient of variation of the estimates; N.A., not assessed (no inhibition found at any of the assayed concentrations, up to 50 μM).