TABLE 5

Repaglinide fraction metabolized via CYP2C8, CYP3A4, and UGT enzymes in pooled human hepatocytes, human liver microsomes, and human S9 fractions

In Vitro SystemfmCYP2C8fmCYP3A4fmUGT
Hepatocytes0.490.490.02
S90.410.390.20
HLM0.630.180.19