Exposure of lixivaptan and metabolites in human, dog, and rat after administration of a single oral dose of [14C]lixivaptan
| Metabolite | Exposure (AUC0–24 h) of Metabolites | |||
|---|---|---|---|---|
| Human | Dog | Male Rat | Female Rat | |
| ng Eq · h/ml | ||||
| Parent | 1860 ± 305 | 11,200 | 632 | 5580 |
| M1 + M2 + M3 | 8100 ± 2340 | 13,070 | 832 | 7960 |
| Unidentified | 406 ± 63 | N.D. | N.D. | N.D. |
| M4 | 268 ± 128 | N.Q. | N.D. | N.D. |
| M5 | 2680 ± 562 | N.Q. | N.Q. | N.Q. |
| M6 | 5180 ± 1830 | 22,400 | 32,100 | 11,100 |
| M7 + M8 | 652 ± 153 | 5640 | 432 | 1050 |
N.D., not detected; N.Q., not quantified.