Metabolite | Retention time | % Plasma Radioactivity | ||||||
---|---|---|---|---|---|---|---|---|
0.5 h | 2 h | 4 h | 8 h | 12 h | 24 h | 36 h | ||
min | ||||||||
Parent | 34.3 | 43.5 ± 7.2 | 13.4 ± 2.3 | 8.0 ± 2.2 | 6.7 ± 4.2 | 5.6 ± 2.4 | 5.5 ± 4.5 | 3.6 ± 3.4 |
M1, M2, M3 | <18 | 31.3 ± 7.7 | 40.3 ± 7.4 | 40.3 ± 5.7 | 37.3 ± 5.2 | 42 ± 7.8 | 32.3 ± 5.3 | 30.9 ± 7.8 |
Unknown | 18.2 | 3.6 ± 1.7 | 3.9 ± 1.5 | 3.0 ± 1.1 | 1.6 ± 0.5 | 1.2 ± 0.5 | 3.0 ± 0.4 | |
M4 | 20.2 | 0.6 ± 0.5 | 1.5 ± 0.8 | 2.5 ± 1.0 | 2.4 ± 1.1 | 2.1 ± 0.5 | 2.1 ± 0.4 | |
M5 | 23.3 | 4.1 ± 1.9 | 16.5 ± 4.4 | 16.8 ± 2.1 | 12.2 ± 1.3 | 11.2 ± 5.0 | 11 ± 5.1 | 7.6 ± 2.4 |
M6 | 24.5 | 1.5 ± 0.8 | 12.6 ± 2.3 | 19.6 ± 4.4 | 28.4 ± 7.9 | 30.1 ± 4.3 | 38.8 ± 12.5 | 35.2 ± 3.2 |
M7 | 25.2 | 2.7 ± 0.5 | 2.2 ± 0.5 | 2.4 ± 1.3 | 2.1 ± 0.6 | 1.6 ± 0.7 | 4.2 ± 1.9 | 3.8 ± 1.2 |
M8 | 26.3 | 4.5 ± 1.1 | 3.7 ± 1.2 | 3.1 ± 0.1 | 1.6 ± 0.5 | 2.4 ± 1.0 | 0.8 ± 0.2 |