Species-dependent affinity of PEPT1 for glycylsarcosine
| Animal Species | GlySar Km | Experimental Conditions for Uptake | Reference |
|---|---|---|---|
| mM | |||
| Rabbit | 1.9 | cRNA-injected XLO, TEVC −60 mV, pH 5.5 | Fei et al., 1994 |
| Human | 0.29 | cDNA-transfected HeLa cells, 14C label, pH 6.0 | Liang et al., 1995 |
| Rat | 0.24 | cRNA-injected XLO, 14C label, pH 6.0 | Zhu et al., 2000 |
| Mouse | 0.75 | cRNA-injected XLO, TEVC −60 mV, pH 5.5 | Fei et al., 2000 |
| Sheep | 0.61 | cRNA-injected XLO, TEVC −60 mV, pH 5.5 | Pan et al., 2001 |
| Chicken | 0.47 | cRNA-injected XLO, TEVC −60 mV, pH 6.0 | Chen et al., 2002 |
| 2.6 | cDNA-transfected CHO cells, 3H label, pH 6.0 | ||
| Monkey | 0.35 | cDNA-transfected HeLa cells, 14C label, pH 6.0 | Zhang et al., 2004 |
| Pig | 0.94 | cDNA-transfected CHO cells, 3H label, pH 6.0 | Klang et al., 2005 |
| Salmon | 0.5 | cRNA-injected XLO, TEVC −60 mV, pH 6.5 | Rønnestad et al., 2010 |
XLO, Xenopus laevis oocytes; HeLa, human epithelial cervical adenocarcinoma cells; CHO, Chinese hamster ovary cells; TEVC, two-electrode voltage-clamp electrophysiology; 14C label and 3H label to the radioisotope of GlySar.