Long-term storage stability test for unstable compounds
Average ratio of (unstable structure response/stable reference) at test day/day 1 response ratio ± S.D. n = 8. A ratio between 0.8 and 1.2 is deemed stable.
| Compounds | Test 1 (Day 1) | Test 2 (Day 30–90) | Test 3 (Day 100–180) |
|---|---|---|---|
| Naproxen acyl glucuronide (treated) | 1 | 1.2 ± 0.25 | 0.84 ± 0.28 |
| Naproxen acyl glucuronide (untreated) | 1 | 0.766 ± 0.13 | 0.531 ± 0.25 |
| 2,3-Dihydroxybenzoic acid (treated) | 1 | 1.00 ± 0.06 | 1.02 ± 0.06 |
| 2,3-Dihydroxybenzoic acid (untreated) | 1 | 1.09 ± 0.07 | 0.88 ± 0.05 |
| Carbamazepine-10,11-epoxide | 1 | 1.14 ± 0.04 | 1.00 ± 0.39 |
| N-Acetyl sulfadiazine | 1 | 0.54 ± 0.095 | 0.599 ± 0.117 |
| Methylphenidate (treated) | 1 | 1.24 ± 0.40 | 1.33 ± 0.55 |
| Methylphenidate (untreated) | 1 | 0.893 ± 0.145 | 0.466 ± 0.171 |
| Nicotine iminium ion | 1 | N.A. | N.A. |
N.A., not applicable.