Comparison of predicted clinical drug-drug interactions (fold change in AUC with object drug midazolam) from in vitro kinetic parameters of CYP3A time-dependent inhibitors
Predicted fold change in AUC was calculated using eq. 2.
| Model | Clarithromycin | Mibefradil | Troleandomycin | Verapamil | Fluoxetine |
|---|---|---|---|---|---|
| Range of clinical DDI | 5–8 | 9 | 15 | 3–4 | No interaction |
| Reference | Gorski et al., 1998 | Veronese et al., 2003 | Kharasch et al., 2004 | Backman et al., 1994 | Lam et al., 2003 |
| HLM | 5 | 12 | 23 | 4 | 2 |
| FreshHep | 7 | 6 | 22 | 4 | 2 |
| CryoHep | 11 | 16 | 22 | 10 | 2 |
| HepaRG | 12 | 13 | 21 | 5 | 2 |
FreshHep, freshly plated human hepatocytes; CryoHep, cryopreserved plated human hepatocytes; HepaRG, cryopreserved plated HepaRG.