Relative abundance of circulating metabolites in rats and dogs
Data are means ± S.D.
| Metabolite | % Plasma Radioactivity | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Male Rats | Female Rats | Dogs | |||||||
| 1 h | 8 h | 24 h | 1 h | 8 h | 24 h | 2 h | 8 h | 24 h | |
| Parent | 4.1 ± 0.4 | 29.9 ± 4.2 | 12.2 ± 2.2 | 21.2 ± 6.9 | 14.9 ± 6.7 | 7.4 ± 8.6 | |||
| Unknowna | 1.6 ± 0.2 | 2.4 ± 0.3 | 2.0 ± 0.2 | 4.3 ± 0.5 | 1.1 ± 2.2 | 26.3 ± 2.1 | 42.9 ± 12.8 | ||
| M1 | 7.0 ± 1.3 | 4.2 ± 1.6 | 2.9 ± 5.0 | 13.7 ± 3.8 | 4.7 ± 3.5 | 1.4 ± 2.7 | |||
| M2 | 3.0 ± 0.5 | 4.5 ± 1.1 | 2.1 ± 1.8 | 8.2 ± 1.4 | 2.7 ± 3.3 | 1.6 ± 3.1 | |||
| M3 | 5.4 ± 1.5 | 36.2 ± 2.4 | 25.2 ± 8.3 | 2.6 ± 4.6 | 19.4 ± 3.1 | 11.1 ± 4.0 | 3.9 ± 4.5 | ||
| M5 | N.Q. | N.Q. | N.Q. | N.Q. | N.Q. | N.Q. | N.Q. | N.Q. | N.Q. |
| M6 | 58.5 ± 0.4 | 73.9 ± 2.0 | 67.8 ± 3.1 | 9.0 ± 0.8 | 42.4 ± 12.3 | 97.4 ± 4.6 | 15.3 ± 5.3 | 29.7 ± 7.2 | 38.7 ± 11.7 |
| M7, M8 | 2.8 ± 0.6 | 4.5 ± 0.5 | 2.8 ± 2.5 | 15.6 ± 2.3 | 7.7 ± 1.9 | 1.1 ± 2.1 | |||
N.Q., not quantified.
↵a Eluted close to void volume.