Parent/Metabolite | Biotransformation Reaction(s) | LC Conditions | Q1 | Q3 | CE |
---|---|---|---|---|---|
Naproxen | LC1 | 229 | 169 | −40 | |
Naproxen acyl glucuronide | Glucuronidation | 405 | 229, 185, 169a | −40 | |
Carbamazepine | LC1 | 237 | 194,a 117 | 27, 43 | |
Carbamazepine-10,11-epoxide | Oxidation | 253 | 210,a 180 | 27, 43 | |
Salicylic acid | LC2 | 137 | 109, 93a | −26 | |
2,3-Dihydroxybenzoic acid | Oxidation | 153 | 109† | −26 | |
Sulfadiazine | LC1 | 251 | 156, 108a | 27, 35 | |
N-Acetyl sulfadiazine | N-Acetylation | 293 | 185, 134,a 108 | 27, 35, 35 | |
Methylphenidate | LC1 | 234 | 128,a 115 | 65, 69 | |
Ritalinic acid | Hydrolysis | 220 | 128,a 115 | 65, 69 | |
Nicotine Δ1′,5′-iminium ion | LC3 | 161 | 130,a 118 | 35 | |
Cotinine | Oxidation | 177 | 118, 98, 80a | 35 |
CE, collision energy.
↵a Daughter ions were used in MRM transitions for peak area ratio measurements.