| | mg | | mg | | | | yr | |
Perpetrators of P450 inhibition | | | | | | | | | |
AZ1 | Midazolam | 400 | 5 days, q.d. | 7.5 | Single, day 5 | Fasted | 28 | 18–65 | 0 |
AZ1 | Simvastatin | 400 | 5 days, q.d. | 40 | Single, day 5 | Fasted | 10 | 20–50 | 0 |
AZ2 | Midazolam | 400 | 4 days, q.d. | 7.5 | Single, day 4 | Fasted | 30 | 18–65 | 0.34 |
AZ3 | Midazolam | 125 | 11 days, q.d. | 7.5 | Single, day 11 | Fasted | 12 | 20–49 | 0 |
AZ4 | Metoprolol | 750 | 6 days, bid | 100 | Single, day 6 | Fasted | 14 | 18–65 | 0.34 |
AZ5 | Metoprolol | 500 | 28 days, q.d. | 50 | Single, day 15 | Fasted | 18 | 44–55 | 0.44 |
Victims of P450 inhibition | | | | | | | | | |
AZ6 | Ketoconazole | 400 | 5 days, q.d. | 125 | Single, day 3 | Fasted | 22 | 18–65 | 0.34 |
AZ6 | Verapamil | 240 | 7 days, q.d. | 125 | Single, day 5 | Fasted | 23 | 18–65 | 0.34 |
AZ7 | Ketoconazole | 200 | 10 days, bid | 90 | Single, day 4 | Fasted | 14 | 20–45 | 0.22 |
AZ7 | Diltiazem | 240 | 14 days, q.d. | 90 | Single, day 8 | Fasted | 17 | 20–45 | 0.22 |
AZ8 | Ketoconazole | 200 | 4 days, q.d. | 3 | Single, day 4 | Fed | 4 | 22–40 | 0 |
AZ8 | Ketoconazole | 100 | 4 days, bid | 3 | Single, day 4 | Fed | 8 | 20–40 | 0 |
AZ9 | Itraconazole | 200 | 7 days, q.d. | 10 | Single, day 4 | Fasted | 6 | 30–49 | 0 |
AZ10 | Ketoconazole | 200 | 4 days, q.d. | 25 | Single, day 4 | Fed | 12 | 24–42 | 0 |
Perpetrators or victims of P450 induction | | | | | | | | | |
AZ5 | Rifampicin | 600 | 16 days, q.d. | 500 | Single, day 10 | Fasted | 18 | 27–56 | 0 |
AZ7 | Rifampicin | 600 | 12 days, q.d. | 180 | Single, day 12 | Fasted | 16 | 22–49 | 0.375 |
AZ9 | Rifampicin | 600 | 13 days, q.d. | 15 | Single, day 10 | Fasted | 12 | 20–61 | 0 |
AZ10 | Carbamazepine | 600 | 25 days, q.d. | 300 | 35 days b.i.d. | Fed | 18 | 29–63 | 0.2 |
AZ11 | Midazolam | 10 | 12 days, q.d. | 5 | Single, day 12 | Fed | 24 | 20–49 | 0 |