Summary of the mean (S.D.) pharmacokinetic parameters of oseltamivir and oseltamivir carboxylate after a single oral dose of oseltamivir (30 mg/kg) to adult fasted rats (n = 3/group)
Oseltamivir was dosed either as a water solution, as a solution in milk, or as 125 mM aqueous Gly-Sar. Statistical analysis was performed on Cmax, tmax, AUC0–6h, and AUC0-∞ values; bovine milk (group 2) and Gly-Sar (group 3) treatments were compared with water (group 1). No statistically significant difference was observed.
| Pharmacokinetic Parameter | Oseltamivir | Oseltamivir Carboxylate | ||||
|---|---|---|---|---|---|---|
| Water Group 1 | Bovine Milk Group 2 | Gly-Sar Group 3 | Water Group 1 | Bovine Milk Group 2 | Gly-Sar Group 3 | |
| Cmax, μg/l | 1690 (452) | 1630 (200) | 2070 (101) | 2290 (283) | 1630 (236) | 2560 (533) |
| tmax, h | 0.83 (0.57) | 0.5 (0) | 0.25 (0) | 1.08 (0.38) | 1.92 (1.13) | 1.17 (0.72) |
| AUC0–6h, μg/l · h | 2680 (262) | 3010 (533) | 3780 (821) | 5910 (429) | 5810 (1280) | 8350 (1850) |
| AUC0-∞, μg/l · h | 2710 (271) | 3060 (510) | 3810 (795) | 6140 (502) | 6300 (1310) | 8860 (1420) |